Rating of the best sartans for 2022

Most people over the age of 30 have some kind of health problem. Most often, among them, problems with the cardiovascular system are in the lead. They arise due to the wrong way of life - lack of physical activity, poor diet, excess weight, lack of sleep, etc. One of the main violations is an increase in blood pressure, which is also called hypertension. To treat this condition, a large number of medications are sold that have many side effects.

Since medical science is constantly improving, a large number of new drugs are constantly being introduced. Among the novelties of this kind, sartans can be distinguished - a group of substances that lower blood pressure by reducing the susceptibility of sensitive elements of the endothelium in the cardiovascular system to AT 2 (angiotensin 2 - a substance that forces the walls of blood vessels to contract to increase blood pressure).These drugs were invented in order to reduce the side effects of previously used drugs, as well as restore lost human health. Useful properties of these tablets will be considered further.

In this article, we will tell you what sartans are and what they are for, find out what to look for in order not to make mistakes when choosing, and learn about the benefits and harms of these medicines, compile a rating of high-quality pressure drugs of the latest generation.

Indications for use

This drug is prescribed in the following cases:

• High blood pressure - in most cases, doctors prescribe this group in the presence of the second stage of the disease or more, since the active substances have a pronounced effectiveness, and therefore they can lower the pressure to critical values, due to which uncontrolled use can lead to unpleasant consequences .
• As a substitute for ACE inhibitors when the patient cannot use this group of drugs. Can be used for both primary and secondary blood pressure.
• With chronic heart failure. This therapy is indicated for both men and women.
• If the patient has a tendency to damage other organs, for example, the organs of vision. Blockers with the function of protecting cells can slow down the process of tissue destruction and degeneration.
• To prolong the life of patients who have suffered a myocardial infarction. The functionality of sartans ensures the acceleration of metabolism between cells and its stabilization, having a positive effect on the general condition of the body.

Useful properties of sartans

First of all, these substances are able to lower blood pressure, thereby improving blood circulation, relieving unpleasant symptoms and dangerous conditions of the body.

In addition, they may refuse the following action:

• Improving the general condition of the heart muscle - reducing the load on the myocardium, thereby preventing the occurrence of palpitations, as well as atrial fibrillation.
• A positive effect on the functioning of the brain - improving memory functions, speeding up thought processes, reducing the intensity and frequency of headaches, preventing the likelihood of a brain stroke.
• Improving the functioning of the excretory system, including the kidneys - reducing edema, balancing the mineral balance, etc.
• Improving metabolism - reducing the proportion of produced harmful cholesterol, increasing vascular patency, improving the general condition of the body in diabetes (especially type 2).

It should be noted that a positive result is observed only in those patients who take the drug for a long time. In the case of a single use, only a decrease in blood pressure is manifested.

Doctors note the following advantages of this group - a small list of contraindications, a long period of excretion from the body, and therefore you can take only 1 tablet per day, a low likelihood of side effects, you can use it for the elderly, as well as those with serious health disorders, including including diabetes mellitus. According to studies, sartans prolong life expectancy for patients with cardiovascular diseases by decades, reduce the risk of stroke, and do not have such serious consequences as an increase in the likelihood of oncological diseases (which is noted in analogues).

Dangerous properties of sartans

It should be noted that sartans, like any drug, have certain contraindications and cannot be used in the following cases:

• It is strictly forbidden to use the medicine for patients who are hypersensitive to any component that is part of it. Uncontrolled use can cause allergic reactions, up to anaphylactic shock.
• It is also forbidden to use this substance for women during pregnancy and breastfeeding. Due to the lack of necessary studies, it is not recommended to drink these tablets also for women who are of childbearing age and are not reliably protected due to the fact that there is a potential for pregnancy, and there is information in the scientific literature that the components of sartans can have a negative impact on the fetus. If conception has occurred, you must immediately stop taking the drug.
• With caution, the medicine is prescribed to children, persons with identified circulating blood insufficiency, with kidney diseases, including renal failure, cirrhosis of the liver, and problems in the biliary tract.
• Also, when sartans are co-administered with drugs that retain potassium in the body, their compatibility should be assessed.

Rating of the best sartans

Depending on which active substance is used in the drug, the following varieties are distinguished: tetrazole derivatives - biphenyl, non-heterocyclic and non-biphenyl. There is also another group that includes the latest developments in the field of medical science - these are the latest generation of non-biphenyl tetrazole derivatives.

Biphenyl derivatives of tetrazole

Candesartan

The release form of the drug is tablets of 8, 16, and 32 milligrams. The active substance is cilexicil canderastan, auxiliary substances are cellulose, starch, lactose, magnesium stearate, etc. The receptor blocker constricts blood vessels, stimulates water balance. Approximately in 2 hours the therapeutic result is shown. The pressure decreases smoothly, without sudden jumps. The duration of the receptor blocker is a day or more. For a pronounced result, it is recommended to take the tablets for a long period (at least 1 month).

According to ongoing studies, people with chronic heart failure, with continued use, have seen a decrease in the number of hospitalizations, as well as the number of deaths due to the crisis. Sartans of this group can be drunk at any time of the day, regardless of food intake and drinking. The drug is excreted through the kidneys and choleretic system.It does not accumulate in the body and is excreted unchanged. The initial dose is 8 mg per day, for the elderly it does not require adjustment. For those diagnosed with impaired liver or kidney function, start with 4 mg. There are not many contraindications and side effects for tablets, the main ones are weakness, nausea, and allergic reactions. It is not recommended to prescribe a blocker to children under 18 years of age, women during pregnancy and breastfeeding, with severe impairment of liver and kidney function, and those who are sensitive to any component of the drug. The product is sold under the trademarks: Gypsum Cart, Xarten, Atakand, etc. The average price of a package is about 300 rubles.

• can be consumed regardless of the meal;
• fast and visible results;
• gradual pressure drop.

• not suitable for children, as well as persons with diabetes mellitus, severely impaired liver and kidney function.

Losartan

The review continues with a remedy based on losartan potassium. There are two main brands of medicine on sale - Losartan and Lozap. The first is about 2.5 times cheaper than the second. This is due to the manufacturer, as well as the degree of purification of the source material. Release form - tablets. According to customer reviews, they are small in size and have a bitter aftertaste, so it is recommended to drink them with plenty of water.

In the package, along with the blister, there is an instruction for use with a detailed description of the pharmacological properties, side effects, precautions and contraindications.The list of contraindications is large, the main ones are pregnancy and lactation, childhood, hypersensitivity to any component that is part of the tablets.

You need to take only 1 tablet per day, drinking it with plenty of water, regardless of the meal. According to buyers, the effect of Losartan is cumulative, the visible result appears a few weeks after the start of use. According to the advice of buyers who use these pills for a year or more, there is no need to overpay for a more expensive analogue, since the budget Losartan works just as well. In Russia, the well-known company OZON is engaged in the manufacture of the drug, and it can be ordered online in an online store much cheaper than in a pharmacy. For a blister of 50 pieces, you will have to pay about 50 rubles, a package of 100 pieces costs 85 rubles.

• inexpensive in price, which is the main selection criterion for most Russians;
• visible result;
• smooth pressure drop;
• buyers do not have problems with where to buy packaging - it is possible to order delivery to any city through the company's online store of the Russian manufacturer.

• bitter taste of tablets;
• some customers report side effects some time after use.

Irbesartan

The main active ingredient of the tablets is irbesartan hydrochloride. The drug is available in 3 different types of packaging - blisters of 75 mg, 150 mg, 300 mg. The pressure receptor blocker performs its main function, while not affecting the concentration of uric acid, glucose and cholesterol in the body.He showed himself best of all in the treatment of chronic heart and kidney failure.

The maximum concentration in the blood occurs after 2 hours, the effect persists for a day or more. Visible improvement occurs a week after the start of use. The half-life is observed after 15 hours, the components are excreted unchanged, mainly through the kidneys. Accumulative accumulation was not found. The list of contraindications is small, compared to what such drugs have - childhood, allergic reactions, pregnancy and breastfeeding.

Patients note the following side effects: nausea, weakness, dizziness, tachycardia, cough, allergic reactions. To ensure a therapeutic result, it is enough to take one tablet a day, regardless of the meal. In case of an overdose, tachycardia or bradycardia may appear, as well as a decrease in blood pressure to critical values. Tablets are sold by prescription only. According to customer reviews, the treatment is easily tolerated, side effects are rare. Compared to Valsartan, the result is more pronounced and long-term. The average price of a package is 550 rubles.

• a small number of contraindications and side effects, dry cough does not appear, which compares favorably with the drug from by-catch;
• you can take only one tablet per day;
• can be used by diabetics.

• high price.

Non-heterocyclic tetrazole derivatives

Valsartan

The main purpose of the substance is the treatment of arterial hypertension, as well as chronic heart failure.The active ingredient selectively blocks receptors that are responsible for increasing pressure, while not inhibiting ACE.

The first effect is manifested already 2 hours after use, the maximum effectiveness is revealed after 4-5 hours. Active components are quickly absorbed and excreted from the gastrointestinal tract unchanged. The concentrations of the active substance in the female and male body are equal. The drug is rapidly absorbed in the gastrointestinal tract, excreted in the following ratio - 70% with feces, 30% - with urine. The first effect of the intake begins to appear 2 hours after use, the pronounced effectiveness appears after 4 hours or more. After 4 months of continuous use, the effect can last for 48 hours or more.

This medicine is the most researched in its group - its effects on the body have been evaluated in more than 140,000 people, as a result of which, the relative safety has been clinically proven. According to doctors, these pills are best prescribed to quickly reduce pressure, but can also be used in the long term. It should be noted that due to large-scale studies of the drug, in the United States it is even approved for use in childhood, but in Russia this is unacceptable.

According to buyers, this is one of the most budgetary means of the sartans group. Available in concentrations of 40, 80, 160 mg. Contraindications include childhood and pregnancy. According to the recommendations of doctors, you should not drink Valsartan while breastfeeding - in studies on rats, the release of the active ingredient with milk has been proven.

The most common side effects are hypotension, dizziness, nausea and diarrhea, weakness, dry persistent cough, decreased immunity, allergic reactions (rash, itching, swelling). It is worth noting that most of the above side effects are extremely rare. It is not recommended to prescribe the drug to patients who use diuretics, heparin, lithium carbonate. Tablets are taken once or twice a day, the maximum dose is 320 mg per day, divided into 2 times.

In 2018, during regular studies, the presence of carcinogenic substances was found in tablets manufactured in the People's Republic of China. In Russia, during this period, a large-scale campaign was carried out to withdraw these drugs from circulation. The following year, the content of such components was found in the tablets of the Japanese company Pfizer. There are a large number of trade names for Valsartan - Valsakor, Diovan, Nortivan, Valz, Sartavel, etc. The average price of a package, depending on the manufacturer, is 200 rubles or more.

• proven safety;
• pronounced therapeutic effect;
• a large number of trade names, thanks to which you can buy a blister with the best value for money, while you can find out how much this or that name costs via the Internet;
• unlike analogues, it is possible to use in childhood;
• given in any pharmacy.

• the price of goods from the best manufacturers differs several times from that at which Russian products are sold, which is why most patients are forced to buy not the highest quality Russian analogue;
• in some tablets of this group, carcinogenic components were identified.

Non-biphenyl derivatives of tetrazole

Eprosartan

The effect of the drug after a single application occurs after two hours and persists throughout the day. With prolonged use (2 weeks or more), a persistent therapeutic effect is manifested, while the heart rate does not change. Compared with ACE inhibitors, such a side effect as a persistent dry cough is much less common. The frequency of occurrence of such a phenomenon is 1.5%.

Doctors note a high connection with blood proteins (up to 98%), while the concentration of the substance is maintained at this level throughout the entire period of admission, regardless of the gender and age of the patient. The drug is excreted through the feces (90%) and kidneys (7%) unchanged, does not accumulate in the body. Dose adjustment is not required for elderly patients, as well as those with renal insufficiency.

With regards to Eprosartan, two large-scale studies were conducted in patients with type 2 diabetes mellitus, as well as cardiovascular and cerebrovascular diseases. Based on the results of these studies, the following conclusions were made: the drug is recommended to be prescribed separately from ACE inhibitors and ARA II, as the risk of hyperkalemia, arterial hypertension, and acute kidney injury increases. It is also not recommended to prescribe Eprosartan together with Aliskiren, since not only side effects were noted, but also an increased risk of death.

Of the contraindications to the use of Eprosartan, pregnancy, breastfeeding, serious disorders in the functioning of the renal system, childhood, simultaneous administration with the drugs mentioned above can be distinguished. Side effects: headache, problems with the gastrointestinal tract, rhinitis, allergic skin reactions, kidney failure in patients with impaired functioning of this system. Data on the effects of an overdose are practically absent. There is only information that one of the patients had a vascular collapse after taking a large dose, but after treatment he completely recovered. Among other consequences, a serious decrease in blood pressure can be noted.

The trade names of the product are Teveten, Eprosartan mesylate and Naviten. The average price of a package is 1,000 rubles. In addition to arterial hypertension, other indications for the use of the drug are the following diseases: hypertension (especially with an increase in myocardium), as a prophylactic agent for the likelihood of a heart attack and stroke, heart failure, pathologies in the renal system, atherosclerotic and vascular disorders.

• there is no side effect that is often found in analogues of this drug - a dry persistent cough;
• showed itself well when prescribed to patients after a heart attack - the survival rate is significantly increased;
• in case of an overdose, there are no serious health problems;
• rare side effects;
• to correct the pressure, it is enough to use one tablet per day.

• high price;
• some patients noted in the first days of taking the drug disorders of the nervous system (dizziness, weakness, nausea), which may interfere with the work with complex mechanisms and driving.

Nebifinyl derivatives of tetrazole of the latest generation

The drugs of this group have a number of characteristics that radically distinguish them from their predecessors. When choosing a drug from which company it is better to buy, we recommend paying attention to this particular group - they have a minimum of adverse reactions, and affect the human body in a complex (suppress all angiotensin receptors at once).

Unfortunately, only one remedy is officially registered in Russia - Telmisartan, all the rest are still outside the law. Therefore, before choosing a particular name on the Internet, you should find out if it is accredited in our country.

Telmisartan

Most often, this drug can be found in pharmacies under the brand name Micardis. There are also such names as Telzap, Telmista, Telsartan, Prytor, Teseo, etc. In addition to the main active ingredient, the drug also contains the following components: sodium hydroxide, magnesium stearate, povidone K25, etc.

The main purpose is primary or secondary hypertension. The active ingredient blocks angiotensin II receptors, with an increase in dosage it also regulates the level of sodium and chlorides, diuresis. It has the function of protecting the kidneys, reduces damage to the myocardium. The tool is able to control both types of blood pressure without affecting the heart rate.

Studies have shown that the substance is well absorbed through the gastrointestinal tract, while it is excreted from the body slowly, more than a day, most of it with feces (80%), the rest with urine.

Blood pressure begins to decrease 3 hours after taking the pill, the effect persists for 3 hours or more, and becomes stable after a month or two after the start of use. After the patient stops drinking the pills, the indicators gradually return to their original values ​​within a few days. There is no withdrawal syndrome. The effectiveness of the drug in young and old people does not differ. This medicine is often prescribed to patients over 55 years of age who have impaired cardiovascular function, which helps to reduce the death rate, as well as hospitalizations associated with heart attacks and strokes.

Unlike most drugs, the list of contraindications is small - pregnancy, breastfeeding, hypersensitivity to any component that is part of the drug, severe liver and kidney dysfunction. There are restrictions on the use of the drug by children, since large-scale studies of the effects on their body have not been conducted. It is also worthwhile to prescribe Telmisartan with caution to persons with obstructive cardiomyopathy, stenosis of the heart valves, chronic heart failure, disorders in the functioning of the kidneys and liver in the initial stage, reduced volume of circulating blood, if they belong to the Negroid race.

Telmisartan should be taken once a day, regardless of the meal. Depending on the disease, the initial dose is 20, 40, or 80 mg.It should be borne in mind that the required therapeutic effect is achieved 4-8 weeks after the start of administration, therefore, dose adjustments at the initial stages of use are not made. For patients with renal insufficiency, the maximum dosage is 40 mg per day.

The most common side effects are weakness, increased fatigue, allergic manifestations in the form of skin rash and itching, excessive lowering of blood pressure, the occurrence of infections of the genitourinary and respiratory systems. There have been no confirmed cases of overdose. It is assumed that the following conditions may occur: extreme low blood pressure, tachycardia, bradycardia, weakness and dizziness. In case of an overdose, you should immediately seek help from a medical facility, provide peace and fresh air for the patient. If a small amount of time has passed after taking the medicine, it is recommended to induce vomiting and flush the stomach, otherwise the use of specific medications is necessary.

When using Telmisartan, patients are advised to drive a car and complex machinery with caution, as it can cause drowsiness and dizziness.

In pharmacies, goods are sold only by prescription, depending on the number of tablets and dosage, the average price of a package is 300 - 400 rubles.

• has a small number of side effects and contraindications;
• does not affect the heart rate, so that the drug can be prescribed to patients at risk for the relevant diseases;
• well tolerated by most patients;
• budget price.

• some patients report difficulty finding over-the-counter drugs.

Conclusion

When choosing which drug of the sartans group is better to buy, you should not prescribe it yourself, if you do not have a specialized medical education. It must be remembered that these are prescription drugs that have an impressive list of side effects and contraindications, and when self-medicated, they can harm human health. We hope that our article will help you make the right choice!